General Cell Lines and Cell Cultures
ATCC Quantitative Genomic DNA from; Leishmania major
Quantitative genomic DNA from Leishmania major can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine protozoan load.
Sigma Aldrich Fine Chemicals Biosciences Skeletal Muscle Cell Growt
Skeletal Muscle Cell Growth Medium (Ready-to-use)
Eurofins Discoverx ChemiBrite FP Prostanoid Receptor Stable Cell Line, 2 vials. (HTS093L)
The ChemiBrite FP Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin F2a) based activation of PTGFR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGFR, a naturally Gq coupled GPCR. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGFR, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx InCELL Hunter HEK 293 BRD2(1) Bromodomain Cell Line, 2 vials. (96-0004C1)
The InCELL Hunter HEK 293 BRD2(1) Bromodomain Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of BRD2(1) via detection of BRD2(1) levels. This product uses EFC technology. The cell line included overexpresses BRD2(1) target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/epigenetics.
Eurofins Discoverx ChemiBrite GPBA Bile Acid Receptor Stable Cell Line, 2 vials. (HTS238L)
The ChemiBrite GPBA Bile Acid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. lithocholic acid, other bile acids) based activation of GPBAR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GPBAR1 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of GPBAR1, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen NK3 Tachykinin Receptor Stable Cell Line, 2 vials. (HTS190C)
The ChemiScreen NK3 Tachykinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. tachykinins) based activation of TACR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TACR3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of TACR3, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Lactobacillus fermentum; Strain: L888
Lactobacillus fermentum strain L888 was isolated from saliva. This bacterial strain is grown aerobically in lactobacilli MRS medium.
ATCC Aspergillus parasiticus
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
ATCC Lactobacillus acidophilus
Lactobacillus acidophilus strain [43] is a quality control strain. This bacterium is propagated in a 5% CO2 atmosphere on lactobacilli MRS medium.
ATCC Trypanosoma cruzi; Y
Trypanosoma cruzi strain Y is a parasitic protozoan that was isolated from a Chagas' disease patient in Brazil. This strain has applications in vector-borne disease research.
Amsbio LLC Lyophilized exosomes from Urine of Healthy donors
Lyophilized exosomes from Urine of Healthy donors
Eurofins Discoverx Ready-to-Assay V 1A Vasopressin Receptor Frozen Cells, 2 Vials of Cells. (HTS059RTA)
The Ready-to-Assay V 1A Vasopressin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. vasopressin) based activation of AVPR1A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AVPR1A alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of AVPR1A, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
